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Extract from Induces the Cell Death of Colorectal Cancer Stem Cells.

著者 Soares Machado M , Palma A , Panelo LC , Paz LA , Rosa F , Lira MC , Azurmendi P , Rubio MF , Lenz G , Urtreger AJ , Costas MA
Nutr Cancer.2019 Oct 01 ; ():1-14.
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Cancer stem cells (CSCs) are an important player in the resistance of cancers to therapy. In this work, we determined the flavonoids composition and biological action of (AP) extracts in colorectal cancer. The chemical characterization of extracts was performed by HPLC. Assays of cytotoxicity, apoptosis, migration and invasion, metalloproteases activity, clonogenic growth, tumorspheres formation, Hoechts efflux, pluripotency marker expression and sensitization to chemotherapeutic drugs were performed in human HCT116 and murine CT26 colorectal cancer cells. The AP toxicity and effect in tumor growth administered alone or in combination with 5- Fluorouracile was analyzed , including histopathological studies. We found that AP extracts induced the apoptosis of colorectal cancer cell lines decreasing the CSC proportion. Moreover, they were capable to kill 5-Fluorouracile resistant side population cells. At not toxic doses , AP extracts inhibited tumor growth. Regarding the ability to reduce the CSC population, AP extracts deserves to be investigated as a useful therapy for colorectal cancer treatment. Abbreviations AP CSC cancer stem cell 5-FURA 5-fluorouracile.
PMID: 31573355 [PubMed - as supplied by publisher]
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