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腸内ウイルス由来の酵素で原因菌を破壊 大阪市大と東大の研究チーム (毎日新聞)

[PR] 腸内細菌のウイルス感染状況を網羅的に調べることで、偽膜性腸炎の原因菌を破壊する抗菌物質を見つけ出す方法を開発したと、大阪市大と東京大の研究チームが発表...

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Extract from Induces the Cell Death of Colorectal Cancer Stem Cells.

著者 Soares Machado M , Palma A , Panelo LC , Paz LA , Rosa F , Lira MC , Azurmendi P , Rubio MF , Lenz G , Urtreger AJ , Costas MA
Nutr Cancer.2019 Oct 01 ; ():1-14.
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Cancer stem cells (CSCs) are an important player in the resistance of cancers to therapy. In this work, we determined the flavonoids composition and biological action of (AP) extracts in colorectal cancer. The chemical characterization of extracts was performed by HPLC. Assays of cytotoxicity, apoptosis, migration and invasion, metalloproteases activity, clonogenic growth, tumorspheres formation, Hoechts efflux, pluripotency marker expression and sensitization to chemotherapeutic drugs were performed in human HCT116 and murine CT26 colorectal cancer cells. The AP toxicity and effect in tumor growth administered alone or in combination with 5- Fluorouracile was analyzed , including histopathological studies. We found that AP extracts induced the apoptosis of colorectal cancer cell lines decreasing the CSC proportion. Moreover, they were capable to kill 5-Fluorouracile resistant side population cells. At not toxic doses , AP extracts inhibited tumor growth. Regarding the ability to reduce the CSC population, AP extracts deserves to be investigated as a useful therapy for colorectal cancer treatment. Abbreviations AP CSC cancer stem cell 5-FURA 5-fluorouracile.
PMID: 31573355 [PubMed - as supplied by publisher]
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