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Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.

著者 González-Cuesta M , Goyard D , Nanba E , Higaki K , García Fernández JM , Renaudet O , Ortiz Mellet C
Chem Commun (Camb).2019 Oct 09 ; ():.
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Multivalent mannosides with inherent macrophage recognition abilities, built on β-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal β-glucocerebrosidase or α-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design.
PMID: 31596280 [PubMed - as supplied by publisher]
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