Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands.

PMID:31611218
Takeshita M , Suzuki K , Kaneda Y , Yamane H , Ikeura K , Sato H , Kato S , Tsunoda K , Arase H , Takeuchi T
Annals of the rheumatic diseases
Recent evidences have revealed that anti-SSA/SSB antibodies, the major autoantibodies in Sjögren's syndrome (SS), are produced in salivary glands. This study aims to clarify overall of autoantibody production at lesion site, including anti-centromere antibody (ACA)-positive SS.


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