絞り込み

17394

広告

腸内ウイルス由来の酵素で原因菌を破壊 大阪市大と東大の研究チーム (毎日新聞)

[PR] 腸内細菌のウイルス感染状況を網羅的に調べることで、偽膜性腸炎の原因菌を破壊する抗菌物質を見つけ出す方法を開発したと、大阪市大と東京大の研究チームが発表...

  1. アビガン、有効性判断できず 藤田医大が臨...
  2. 「療養状況等及び入院患者受入病床数等に関...
  3. SBをスタンドで応援する犬型ロボット そ...
  4. 接触確認アプリ(COCOA)に陽性者とし...

ニュース一覧

Direct interplay between stereochemistry and conformational preferences in aminoacylated oligoribonucleotides.

著者 Polyansky AA , Kreuter M , Sutherland JD , Zagrovic B
Nucleic Acids Res.2019 Oct 15 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)

Full Text Sources

To address the structural and dynamical consequences of amino-acid attachment at 2'- or 3'-hydroxyls of the terminal ribose in oligoribonucleotides, we have performed an extensive set of molecular dynamics simulations of model aminoacylated RNA trinucleotides. Our simulations suggest that 3'-modified trinucleotides exhibit higher solvent exposure of the aminoacylester bond and may be more susceptible to hydrolysis than their 2' counterparts. Moreover, we observe an invariant adoption of well-defined collapsed and extended conformations for both stereoisomers. We show that the average conformational preferences of aminoacylated trinucleotides are determined by their nucleotide composition and are fine-tuned by amino-acid attachment. Conversely, solvent exposure of the aminoacylester bond depends on the attachment site, the nature of attached amino acid and the strength of its interactions with the bases. Importantly, aminoacylated CCA trinucleotides display a systematically higher solvent exposure of the aminoacylester bond and a weaker dependence of such exposure on sidechain interactions than other trinucleotides. These features could facilitate hydrolytic release of the amino acid, especially for 3' attachment, and may have contributed to CCA becoming the universal acceptor triplet in tRNAs. Our results provide novel atomistic details about fundamental aspects of biological translation and furnish clues about its primordial origins.
PMID: 31612955 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード