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HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes.

著者 Huang H , Fan Y , Gao Z , Wang W , Shao N , Zhang L , Yang Y , Zhu W , Chen Z , Hu J , Ding G
BMC Pharmacol Toxicol.2019 Oct 17 ; 20(1):59.
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Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD). As Angiotensin II (Ang II) is a critical active effector in the renin-angiotensin system (RAS) and was proved to be closely related to the inflammatory injury. Meanwhile, researchers found that Ang II could alter the expression of HIF-1α in the kidney. However, whether HIF-1α is involved in mediating Ang II-induced inflammatory injury in podocytes is not clear.
PMID: 31623681 [PubMed - in process]
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