Inhibition of core fucosylation limits progression of diabetic kidney disease.

PMID:31623829
Fang M , Kang L , Wang X , Guo X , Wang W , Qin B , Du X , Tang Q , Lin H
Biochemical and biophysical research communications
FUT8-mediated core fucosylation, which transfers a fucose residue from GDP-fucose to core-GlcNAc of the N-linked type glycoproteins, is crucial for signaling receptors function. Core fucosylation is involved in various biological processes such as cell proliferation, apoptosis, differentiation and immune regulation. Our previous studies demonstrated that inhibiting core fucosylation prevented renal interstitial fibrosis of UUO murine models, but its role in the development of diabetic kidney disease (DKD) remains unclear. This study aimed to clarify the protective effects and molecular mechanisms during the progress of DKD by inhibiting core fucosylation in vivo.


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