絞り込み

16643

広告

診療報酬「本体」0.55%引き上げ 前回と同水準 政府方針 (毎日新聞)

麻生太郎副総理兼財務相=川田雅浩撮影 [PR] 政府は13日、2020年度の診療報酬の改定で、医師の技術料にあたる「本体部分」を0・55%引き上げる方針を固めた...

  1. ベースラインctDNA解析での変異の有無...
  2. 脳転移患者も含む多数の治療歴を持つHER...
  3. 手術可能なルミナールB乳癌の術前療法でr...
  4. TNBCの術前化学療法へのペムブロリズマ...

ニュース一覧

Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABA receptors.

著者 Teoh J , Subramanian N , Pero ME , Bartolini F , Amador A , Kanber A , Williams D , Petri S , Yang M , Allen AS , Beal J , Haut SR , Frankel WN
Neurobiol Dis.2019 Oct 30 ; ():104632.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (2view , 0users)

Full Text Sources

ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. To model ARFGEF1 haploinsufficiency observed in a recent Lennox Gastaut Syndrome patient, we studied a frameshift mutation (Arfgef1) in mice. Arfgef1 pups exhibit signs of developmental delay, and Arfgef1 adults have a significantly decreased threshold to induced seizures but do not experience spontaneous seizures. Histologically, the Arfgef1 brain exhibits a disruption in the apical lining of the dentate gyrus and altered spine morphology of deep layer neurons. In primary hippocampal neuron culture, dendritic surface and synaptic but not total GABA receptors (GABAR) are reduced in Arfgef1 neurons with an accompanying decrease in the number of GABAR-containing recycling endosomes in cell body. Arfgef1 neurons also display differences in the relative ratio of Arf6:Rab11:TrfR recycling endosomes. Although the GABAR-containing early endosomes in Arfgef1 neurons are comparable to wildtype, Arfgef1 neurons show an increase in the number of GABAR-containing lysosomes in dendrite and cell body. Together, the altered endosome composition and decreased neuronal surface GABAR results suggests a mechanism whereby impaired neuronal inhibition leads to seizure susceptibility.
PMID: 31678406 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード