絞り込み

18370

広告

Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common isoforms abolished.

著者 Zhang M , Ibañez DP , Fan W , Liu H , Zhong X , Wang X , Li Y , Md Abdul M , Li W , Li Y , Ward C , Chen S , Wang D , Qin B , Esteban MA , Zhao P , Luo Z
Stem Cell Res.2019 Oct 15 ; 41():101602.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (15view , 0users)

Full Text Sources

Medical

Research Materials

GIBHi002-A (CVCL_YC25)

GIBHi002-A-1 (CVCL_YC27)

Loss of function mutations in PARK2 (encoding PARKIN) cause autosomal recessive Parkinson's disease (PD), which often manifests at a juvenile age. Molecular and biochemical studies show that PARKIN functions as an E3 ubiquitin ligase controlling mitochondrial homeostasis. Yet, the exact mechanisms are unclear due to the use of sub-optimal models including cancer cells and fibroblasts. We have generated a PARK2 knockout (KO) isogenic cell line using a well-characterized induced pluripotent stem cell (iPSC) clone with good differentiation potential. This cell line lacks the expression of all PARKIN isoforms and is valuable for elucidating the role of PARK2 mutations in PD.
PMID: 31698191 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード