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がん種類別・ステージ別 5年生存率の詳細データ (NHK)

国立がん研究センターが発表した、5年生存率のがんの種類・ステージ別のデータは以下のとおりです。全体の生存率が高い順に示します。 前立腺がん ▽ステージ1=100...

  1. がん 5年生存率 全体で66.4% 最高...
  2. 首位アジルバがオルメテックを大きく突き放...
  3. 【動画】この薬を食前に飲んで下さい。 (...
  4. 遺伝性乳がん 予防切除、保険適用 中医協...

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Axonal degeneration in an in vitro model of ischemic white matter injury.

著者 Cui Y , Jin X , Choi DJ , Choi JY , Kim HS , Hwang DH , Kim BG
Neurobiol Dis.2019 Nov 07 ; ():104672.
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Ischemic white matter injuries underlie cognitive decline in the elderly and vascular dementia. Ischemia in the subcortical white matter is caused by chronic reduction of blood flow due to narrowing of small arterioles. However, it remains unclear how chronic ischemia leads to white matter pathology. We aimed to develop an in vitro model of ischemic white matter injury using organotypic slice cultures. Cultured cerebellar slices preserved fully myelinated white matter tracts that were amenable to chronic hypoxic insult. Prolonged hypoxia caused progressive morphological evidence of axonal degeneration with focal constrictions and swellings. In contrast, myelin sheaths and oligodendrocytes exhibited remarkable resilience to hypoxia. The cytoskeletal degradation of axons was accompanied by mitochondrial shortening and lysosomal activation. Multiple pharmacological manipulations revealed that the AMPA glutamate receptor, calpain proteolysis, and lysosomal proteases were independently implicated in hypoxia-induced axonal degeneration in our model. Thus, our in vitro model would be a novel experimental system to explore molecular mechanisms of ischemic white matter injury. Furthermore, we verified that the in vitro assay could be successfully utilized to screen for molecules that can ameliorate hypoxia/ischemia-induced axonal degeneration.
PMID: 31707117 [PubMed - as supplied by publisher]
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