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「頑張っている薬剤師への評価を」 (日経BP)

2020年1月24日、中央社会保険医療協議会(中医協)総会は、公聴会を開催した。公聴会は、中医協委員が広く国民の声を聞くために開催しており、今回は静岡県富士市の...

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Development and verification of a nomogram for prediction of recurrence-free survival in clear cell renal cell carcinoma.

著者 Chen Y , Jiang S , Lu Z , Xue D , Xia L , Lu J , Wang H , Xu L , Li L , Li G
J Cell Mol Med.2019 Nov 29 ; ():.
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Nowadays, gene expression profiling has been widely used in screening out prognostic biomarkers in numerous kinds of carcinoma. Our studies attempt to construct a clinical nomogram which combines risk gene signature and clinical features for individual recurrent risk assessment and offer personalized managements for clear cell renal cell carcinoma. A total of 580 differentially expressed genes (DEGs) were identified via microarray. Functional analysis revealed that DEGs are of fundamental importance in ccRCC progression and metastasis. In our study, 338 ccRCC patients were retrospectively analysed and a risk gene signature which composed of 5 genes was obtained from a LASSO Cox regression model. Further analysis revealed that identified risk gene signature could usefully distinguish the patients with poor prognosis in training cohort (hazard ratio [HR] = 3.554, 95% confidence interval [CI] 2.261-7.472, P < .0001, n = 107). Moreover, the prognostic value of this gene-signature was independent of clinical features (P = .002). The efficacy of risk gene signature was verified in both internal and external cohorts. The area under receiver operating characteristic curve of this signature was 0.770, 0.765 and 0.774 in the training, testing and external validation cohorts, respectively. Finally, a nomogram was developed for clinicians and did well in the calibration plots. This nomogram based on risk gene signature and clinical features might provide a practical way for recurrence prediction and facilitating personalized managements of ccRCC patients after surgery.
PMID: 31782902 [PubMed - as supplied by publisher]
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