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Association of Longitudinal β-Amyloid Accumulation Determined by Positron Emission Tomography With Clinical and Cognitive Decline in Adults With Probable Lewy Body Dementia.

著者 Nedelska Z , Schwarz CG , Lesnick TG , Boeve BF , Przybelski SA , Lowe VJ , Kremers WK , Gunter JL , Senjem ML , Graff-Radford J , Ferman TJ , Fields JA , Knopman DS , Petersen RC , Jack CR , Kantarci K
JAMA Netw Open.2019 Dec 02 ; 2(12):e1916439.
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In patients with probable dementia with Lewy bodies (DLB), overlapping Alzheimer disease pathology is frequent and is associated with faster decline and shorter survival. More than half of patients with DLB have elevated β-amyloid levels on carbon-11 labeled Pittsburgh compound B (PiB) positron emission tomography, but the trajectory of longitudinal β-amyloid accumulation and its associations with clinical and cognitive decline in DLB are not known.
PMID: 31790563 [PubMed - in process]
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