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Circulating Brain-enriched MicroRNAs for detection and discrimination of idiopathic and genetic Parkinson's disease.

著者 Ravanidis S , Bougea A , Papagiannakis N , Maniati M , Koros C , Simitsi AM , Bozi M , Pachi I , Stamelou M , Paraskevas GP , Kapaki E , Moraitou M , Michelakakis H , Stefanis L , Doxakis E
Mov Disord.2019 Dec 04 ; ():.
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A minimally invasive test for early detection and monitoring of Parkinson's disease (PD) is a highly unmet need for drug development and planning of patient care. Blood plasma represents an attractive source of biomarkers. MicroRNAs (miRNAs) are conserved noncoding RNA molecules that serve as posttranscriptional regulators of gene expression. As opposed to ubiquitously expressed miRNAs that control house-keeping processes, brain-enriched miRNAs regulate diverse aspects of neuron development and function. These include neuron-subtype specification, axonal growth, dendritic morphogenesis, and spine density. Backed by a large number of studies, we now know that the differential expression of neuron-enriched miRNAs leads to brain dysfunction.
PMID: 31799764 [PubMed - as supplied by publisher]
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