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「核ごみ」国、初の住民説明会 理解求める 北海道・神恵内村 (毎日新聞)

高レベル放射性廃棄物(核のごみ)最終処分場の選定に向けた文献調査応募の動きがある北海道神恵内(かもえない)村で26日夜、資源エネルギー庁と原子力発電環境整備機構...

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Microgliosis is associated with visual memory decline in patients with temporal lobe epilepsy and hippocampal sclerosis: A clinicopathologic study.

著者 Toscano ECB , Vieira ÉLM , Portela ACDC , Caliari MV , Brant JAS , Giannetti AV , Suemoto CK , Leite REP , Nitrini R , Rachid MA , Teixeira AL
Epilepsy Behav.2019 Dec 02 ; 102():106643.
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Hippocampal sclerosis (HS) is characterized by neuronal loss and gliosis. The intensity and distribution of these histopathological findings over the Cornu Ammonis (CA) subfields are important for the classification of HS and prognostication of patients with temporal lobe epilepsy (TLE). Several studies have associated the neuronal density reduction in the hippocampus with cognitive decline in patients with TLE. The current study aimed at investigating whether the expression of glial proteins in sclerotic hippocampi is associated with presurgical memory performance of patients with TLE. Before amygdalohippocampectomy, patients were submitted to memory tests. Immunohistochemical and morphometric analyses with glial fibrillary acidic protein (GFAP) for astrogliosis and human leucocyte antigen DR (HLA-DR) for microgliosis were performed in paraffin-embedded HS and control hippocampi. Sclerotic hippocampi exhibited increased gliosis in comparison with controls. In patients with TLE, the area and intensity of staining for HLA-DR were associated with worse performance in the memory tests. Glial fibrillary acidic protein was neither associated nor correlated with memory test performance. Our data suggest association between microgliosis, but not astrogliosis, with visual memory decline in patients with TLE.
PMID: 31805504 [PubMed - as supplied by publisher]
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