絞り込み

16645

広告

新型肺炎 空港や港の検疫所でもウイルス検査実施へ 厚労省

中国で新型コロナウイルスによる肺炎が拡大する中、厚生労働省は感染者をより早期に発見するため、空港や港にある検疫所でもウイルス検査を実施していくことになりました。...

  1. 「クイーン」のブライアン・メイさん 京都...
  2. 新型肺炎「指定感染症」に きょう閣議決定...
  3. ルマテペロンは統合失調症の症状を軽減 (...
  4. 「嘔吐後の肺炎=誤嚥性肺炎」ではない! ...

ニュース一覧

MiR-215-5p inhibits the inflammation injury in septic H9c2 by regulating ILF3 and LRRFIP1.

著者 Yao Y , Xu K , Sun Y , Tian T , Shen W , Sun F , Yuan W , Wu H , Chen G , Yuan L , Zhang W , Lu M , Lei M
Int Immunopharmacol.2019 Dec 03 ; ():106000.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (2view , 0users)

Full Text Sources

Miscellaneous

MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) playing crucial roles in sepsis-induced diseases, including myocardial inflammation. Nevertheless, the expression pattern and role of miR-215-5p in myocardial inflammation are still un-investigated up to now. The purpose of our study is to further inquire the effect of miR-215-5p on lipopolysaccharide (LPS)-activated inflammation injury in H9c2 cells and the possibly associated mechanisms. First of all, LPS-induced H9c2 cells models were constructed and affirmed via detection of pro-inflammatory factors, the viability and apoptosis. MiR-215-5p was overtly down-regulated in LPS-treated H9c2 cells and miR-215-5p overexpression could suppress the inflammation injury. LRRFIP1 was proved to be the target gene of miR-215-5p and meanwhile, miR-215-5p also targeted ILF3 that experimented to bind to and stabilize LRRFIP1. Final rescue assays confirmed that the overexpression of LRRFIP1 or ILF3 rescued the repressive effect of miR-215-5p up-regulation on the inflammation injury in septic H9c2. Totally, miR-215-5p exerted protective function in the inflammation injury in septic H9c2 via targeting ILF3 and LRRFIP1, suggesting an additional treatment method for sepsis-activated myocardial inflammation.
PMID: 31806569 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード