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Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

著者 Moore KM , Nicholas J , Grossman M , McMillan CT , Irwin DJ , Massimo L , Van Deerlin VM , Warren JD , Fox NC , Rossor MN , Mead S , Bocchetta M , Boeve BF , Knopman DS , Graff-Radford NR , Forsberg LK , Rademakers R , Wszolek ZK , van Swieten JC , Jiskoo
Lancet Neurol.2019 Dec 03 ; ():.
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Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72.
PMID: 31810826 [PubMed - as supplied by publisher]
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