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手塚治虫さん トキワ荘の天井板に描いた直筆画 豊島区に寄贈 (NHK)

マンガの神様、手塚治虫さんが若き日を過ごしたアパート「トキワ荘」の天井板に描いた貴重な直筆画が東京 豊島区に寄贈されました。来月オープンする「トキワ荘」を復元し...

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Evaluation of polymorphisms in microRNA-binding sites and pancreatic cancer risk in Chinese population.

著者 Ke J , Peng X , Mei S , Tian J , Ying P , Yang N , Wang X , Zou D , Yang Y , Zhu Y , Gong Y , Gong J , Zhong R , Chang J , Fang Z , Miao X
J Cell Mol Med.2019 Dec 27 ; ():.
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As promising biomarkers and therapy targets, microRNAs (miRNAs) are involved in various physiological and tumorigenic processes. Genetic variants in miRNA-binding sites can lead to dysfunction of miRNAs and contribute to disease. However, systematic investigation of the miRNA-related single nucleotide polymorphisms (SNPs) for pancreatic cancer (PC) risk remains elusive. We performed integrative bioinformatics analyses to select 31 SNPs located in miRNA-target binding sites using the miRNASNP v2.0, a solid database providing miRNA-related SNPs for genetic research, and investigated their associations with risk of PC in two large case-control studies totally including 1847 cases and 5713 controls. We observed that the SNP rs3802266 is significantly associated with increased risk of PC (odds ratio (OR) = 1.21, 95% confidence intervals (CI) = 1.11-1.31, P = 1.29E-05). Following luciferase reporter gene assays show that rs3802266-G creates a stronger binding site for miR-181a-2-3p in 3' untranslated region (3'UTR) of the gene ZHX2. Expression quantitative trait loci (eQTL) analysis suggests that ZHX2 expression is lower in individuals carrying rs3802266-G with increased PC risk. In conclusion, our findings highlight the involvement of miRNA-binding SNPs in PC susceptibility and provide new clues for PC carcinogenesis.
PMID: 31880394 [PubMed - as supplied by publisher]
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