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新型ウイルス 封鎖から1か月 先行きの見えない街 中国 武漢 (NHK)

新型コロナウイルスの感染が広がっている中国で状況が最も深刻な湖北省武漢では、事実上、街が封鎖される措置がとられてから23日で1か月になります。住民は外出を厳しく...

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The long noncoding RNA regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43.

著者 Keihani S , Kluever V , Mandad S , Bansal V , Rahman R , Fritsch E , Gomes LC , Gärtner A , Kügler S , Urlaub H , Wren JD , Bonn S , Rizzoli SO , Fornasiero EF
Sci Adv.2019 Dec ; 5(12):eaay2670.
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The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function and neuronal activity are largely unexplored. Here, we established an integrated screening strategy to discover lncRNAs implicated in neurotransmitter and synaptic vesicle release. With this approach, we identified , a neuron-specific nuclear lncRNA conserved from rodents to humans. is tuned by synaptic activity and influences several other essential aspects of neuronal development including calcium influx, neuritogenesis, and neuronal migration in vivo. We defined the molecular interactors of in detail using chromatin isolation by RNA purification, RNA interactome analysis, and protein mass spectrometry. We found that the effects of on synaptic vesicle release require interaction with the RNA-binding protein TDP-43 (TAR DNA binding protein-43) and the selective stabilization of mRNAs encoding for presynaptic proteins. These results provide the first proof of an lncRNA that orchestrates neuronal excitability by influencing presynaptic function.
PMID: 31897430 [PubMed - in process]
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