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Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants.

著者 Whitwell JL , Tosakulwong N , Botha H , Ali F , Clark HM , Duffy JR , Utianski RL , Stevens CA , Weigand SD , Schwarz CG , Senjem ML , Jack CR , Lowe VJ , Ahlskog JE , Dickson DW , Josephs KA
Neuroimage Clin.2019 Dec 28 ; 25():102152.
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Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy that is associated with different clinical variants, including PSP-Richardson's syndrome (PSP-RS), PSP-parkinsonism (PSP-P), PSP-corticobasal syndrome (PSP-CBS), PSP-frontal (PSP-F), PSP-progressive gait freezing (PSP-PGF) and PSP-speech/language (PSP-SL). While PSP-RS has been well-characterized on neuroimaging, the characteristics of the other atypical variants are less well defined and it is unknown how they compare to each other or relate to neuropathology. We aimed to assess and compare regional atrophy on MRI and [F]flortaucipir uptake on PET across PSP variants.
PMID: 31935638 [PubMed - as supplied by publisher]
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