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Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults.

著者 Arenaza-Urquijo EM , Przybelski SA , Machulda MM , Knopman DS , Lowe VJ , Mielke MM , Reddy AL , Geda YE , Jack CR , Petersen RC , Vemuri P
Neurology.2020 Jan 21 ; ():.
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Research in animals has shown that chronic stress exacerbates tau pathology. In humans, psychological stress has been associated with higher risk of Alzheimer disease clinical syndrome. The objective of this cross-sectional study was to assess the hypothesis that stress coping ability (assessed via the Brief Resilience Scale [BRS]) is associated with tau burden and to evaluate whether these associations differed by sex and amyloid status (A+/A-) in cognitively unimpaired (CU) older adults.
PMID: 31964689 [PubMed - as supplied by publisher]
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