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Topography of cortical thinning in the Lewy body diseases.

著者 Ye R , Touroutoglou A , Brickhouse M , Katz S , Growdon JH , Johnson KA , Dickerson BC , Gomperts SN
Neuroimage Clin.2020 Jan 31 ; 26():102196.
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Regional cortical thinning in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) may underlie some aspect of their clinical impairments; cortical atrophy likely reflects extensive Lewy body pathology with alpha-synuclein deposits, as well as associated Alzheimer's disease co-pathologies, when present. Here we investigated the topographic distribution of cortical thinning in these Lewy body diseases compared to cognitively normal PD and healthy non-PD control subjects, explored the association of regional thinning with clinical features and evaluated the impact of amyloid deposition.
PMID: 32059167 [PubMed - as supplied by publisher]
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