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胃切除で腸環境悪化 大腸がん関連の細菌増加か 東工大など発表 (毎日新聞)

胃がんで胃を切除すると腸内環境が大きく変わり、大腸がんとの関連が指摘される細菌が増える可能性があるとする研究結果を、東京工業大や大阪大などのチームが発表した。胃...

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Instability of protease production in a rel+/rel- -pair of Bacillus licheniformis and associated morphological and physiological characteristics.

著者 Bulthuis BA , Frankena J , Koningstein GM , van Verseveld HW , Stouthamer AH
Antonie Van Leeuwenhoek.1988 ; 54(2):95-111.
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A naturally occurring relaxed/protease-producing (A-type) versus stringent/not protease-producing (B-type) pair of an industrial Bacillus licheniformis has been characterized; either of the two types can convert into the other. Both types can sporulate, grow anaerobically, grow at 56 degrees C and reduce nitrate; morphologically, they can easily be distinguished by cell- and colony-shape. They differ in the ability to use 12 substrates, as determined in API-tests. The two types are remarkably different in their content of extrachromosomal elements (A-type: 2; B-type: 4); furthermore, they differ in their rel-status (A-type: relaxed; B-type: stringent). We propose that the differences in the ability of the two types to use different substrates probably are due to integration/extrusion of the extrachromosomal elements in and out of the chromosome, distorting or restoring a number of genes, together with induction of certain catabolic genes that are under control of the rel-system.
PMID: 3293529 [PubMed - indexed for MEDLINE]
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