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Hepatolenticular degeneration: histological study of conjunctiva and observation of chalazii during D-penicillamine treatment.

著者 Loffredo A , Sammartino A , Cecio A , Campanella G
Acta Ophthalmol (Copenh).1983 Oct ; 61(5):943-6.
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Three patients with hepatolenticular degeneration (Wilson's disease) are described. Bilateral blepharoconjunctivitis and Kayser-Fleischer ring was observed in all 3 patients. In 2 patients, long-lasting, bilateral chalazii appeared during chronic treatment with D-penicillamine. Histochemical and ultrastructural studies of pre-treatment conjunctival biopsies showed no copper storage in the tissue thus supporting the hypothesis that copper storage in Descemet's membrane derives from the anterior chamber.
PMID: 6659902 [PubMed - indexed for MEDLINE]
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