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Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.

著者 Scott WK , Saunders AM , Gaskell PC , Locke PA , Growdon JH , Farrer LA , Auerbach SA , Roses AD , Haines JL , Pericak-Vance MA
Ann Neurol.1997 Sep ; 42(3):376-8.
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We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD.
PMID: 9307262 [PubMed - indexed for MEDLINE]
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