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子どもが亡くなる病気で最も多い小児がんについて、国は、適切な医療や支援を受けられるようにしようと、全国15か所にある拠点病院への患者の集約を進めていますが、国立...

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「"Lieberman RL "[Author]」の検索結果

70件中 1件~20件表示    検索結果をPubMedで見る PubMedで見る

Different Grp94 components interact transiently with the myocilin olfactomedin domain in vitro to enhance or retard its amyloid aggregation.

Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices.

Progranulin deficiency leads to reduced glucocerebrosidase activity.

Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations.

Antibodies Used to Detect Glaucoma-Associated Myocilin: More or Less Than Meets the Eye?

How does a protein's structure spell the difference between health and disease? Our journey to understand glaucoma-associated myocilin.

Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition.

Differential misfolding properties of glaucoma-associated olfactomedin domains from human and mouse.

Atomic structure of a fluorescent Ag cluster templated by a multi-stranded DNA scaffold.

Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling.

Progress toward development of a proteostasis drug for myocilin-associated glaucoma.

Epitope mapping of commercial antibodies that detect myocilin.

Simulations and Experiments Delineate Amyloid Fibrilization by Peptides Derived from Glaucoma-Associated Myocilin.

Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability.

Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.

Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering.

Trifunctional high-throughput screen identifies promising scaffold to inhibit Grp94 and treat myocilin-associated glaucoma.

Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog.

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.

Structure and Misfolding of the Flexible Tripartite Coiled-Coil Domain of Glaucoma-Associated Myocilin.

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