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Graphene Quantum Dots Wrapped Gold Nanoparticles with Integrated Enhancement Mechanisms as Sensitive and Homogeneous Substrates for Surface-Enhanced Raman Spectroscopy.

著者 Miao X , Wen S , Su Y , Fu J , Luo X , Wu P , Cai C , Jelinek R , Jiang LP , Zhu JJ
Anal Chem.2019 May 07 ; ():.
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Rational engineering of highly stable and Raman-active nanostructured substrates is still urgently demanded for achieving sensitive and reliable surface-enhanced Raman spectroscopy (SERS) analysis in solution phase. Herein, monodisperse N-doping graphene quantum dots wrapped Au nanoparticles (Au-NGQD NPs) were facilely prepared and further explored their applications as substrates in SERS-based detection and cellular imaging. The as-prepared Au-NGQD NPs exhibit superior long-term stability and biocompatibility, as well as large enhancement capability due to the integration of electromagnetic and chemical enhancements. The practical applicability of the Au-NGQD NPs was verified via the direct SERS tests of several kinds of aromatics in solution phase. Finite-difference time-domain (FDTD) simulations in combination with density functional theory (DFT) calculation were also successfully used to explain the enhancement mechanism. Furthermore, the Au-NGQD NPs were conjugated with 4-nitrobenzenethiol (4-NBT, as reporter) and 4-mercaptophenylboronic acid (MPBA, as targeting element) to construct the MPBA/4-NBT@Au-NGQD probes, which could specifically recognize glycan over-expressed cancer cells through SERS imaging on cell surface. The prepared Au-NGQDs show great potential as superior SERS substrates in solution phase for on-site Raman detection.
PMID: 31062958 [PubMed - as supplied by publisher]
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