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A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population.

著者 Zhu Y , Ke J , Gong Y , Yang Y , Peng X , Tian J , Zou D , Yang N , Wang X , Mei S , Rao M , Ying P , Deng Y , Wang H , Zhang H , Li B , Wan H , Li Y , Niu S , Cai Y , Zhang M , Lu Z , Zhong R , Miao X , Chang J
Cancer Med.2019 May 06 ; ():.
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Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K-AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathway. In order to investigate the associations between genetic variations in that pathway and pancreatic cancer prognosis, we conducted a two-stage survival analysis in a total of 547 Chinese pancreatic cancer patients. Consequently, a variant, rs13167294 A>C in PIK3R1, was significantly associated with poor survival in both stages and with hazard ratio being 1.32 (95% CI = 1.13-1.56, P = 0.0007) in the combined analysis. Function annotation and prediction suggested that genetic variants in this locus might affect overall survival of pancreatic cancer patients by regulating PIK3R1 expression.
PMID: 31059194 [PubMed - as supplied by publisher]
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